Weight is rarely a willpower problem, and it's almost never a single problem. Appetite signalling, metabolic markers, sleep, medication history and what happened the last few times you tried all feed into it — which is why the starting point here is an evaluation rather than a prescription.

Your provider reviews your health history and bloodwork, then discusses whether a medically supervised weight programme is appropriate for you, and if so, what form it takes. Some of what's discussed is medication. Much of it isn't — nutrition, protecting lean mass while weight comes down, and what maintenance looks like once you're where you want to be.

The compounds below may come up in that conversation. Which of them are appropriate, if any, is a decision your provider makes with you.